The full texts of papers were retrieved for any titles or abstracts that appeared to satisfy the inclusion criteria, or for which inclusion or exclusion could not be definitely determined. The reference lists of relevant studies were searched for further papers.Ĭitations identified by the searching process were screened by one reviewer (DP or TP) using the inclusion criteria. All searches were initially conducted in August 2009, though updates were undertaken for personality and bipolar disorders until March 2011, and for depression and anxiety until December 2010. Searches were limited to English language only but not by any date restriction. Ten databases were searched for published research from inception: Cochrane Database of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CENTRAL), NHS Economic Evaluation Database (NHS EED), Health Technology Database, Database of Abstracts of Reviews of Effects (DARE), MEDLINE, PreMEDLINE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), EMBASE and Web of Science. Two sets of search terms were combined: terms for each of the four HRQoL measures and terms for each mental health condition (the search strategy is in Appendix 2). Studies that only provided data on other psychometric properties, such as reliability, face validity and content validity, were not included.Ī literature search was performed to identify relevant research for all mental health conditions being investigated within the wider review, using a database thesaurus and free text terms. Responsiveness data had to be in the form of effect sizes, standardised response means (SRMs) or correlation with change scores on symptom measures. known groups, convergent or discriminant) or the responsiveness of the HRQoL instrument(s). The outcomes had to include data that allowed measurement of the construct validity (i.e. Studies whose primary focus was on individuals with alcohol and/or drug dependency were excluded whether or not those individuals had one of the five conditions. their items and dimensions) or health-state utility values generated by the EQ-5D or SF-6D, or the EQ-VAS. HRQoL data could be from descriptive systems (i.e. Studies were eligible for inclusion if they contained HRQoL data obtained using one or more of the instruments under study (SF-36, SF-12, SF-6D or EQ-5D) within the specified population of adults (aged ≥ 18 years) suffering from one of the five conditions. The detailed findings with tables of results by study are available in published articles or in discussion paper form. This chapter presents the methods and an overview of the findings. Four separate systematic reviews were undertaken from one common search of the literature, with depression and anxiety reviewed together. This review covers five mental health conditions: schizophrenia, bipolar disorder, personality disorders, depression and anxiety. It forms the first study presented in this report. The assessment is based on a systematic review of studies reporting one or more of these measures alongside various condition-specific indicators of mental health that can be used to assess validity using known-group comparisons and convergence, and responsiveness to changes in health over time. This chapter examines the validity and responsiveness of two generic preference-based measures of health (the EQ-5D and SF-6D) and two related generic non-preference-based measures (the SF-36 and SF-12) in populations with mental health problems.
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